Reply

We thank the authors for their interest in our article about relative adrenal insufficiency (RAI) in patients admitted for acute decompensation of cirrhosis.1 The authors correctly pointed out that we highlighted the role of the deficiency of substrates of steroidogenesis and inflammation as relevant mechanisms involved in the pathophysiology of RAI. However, we stated the pathogenesis of RAI is much more complex in patients with cirrhosis, and we fully agree with the authors that abnormalities of hypothalamic-pituitary-adrenal axis can be relevant in the pathogenesis of RAI.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research