Adamantinoma Mimicking Squamous Cell Carcinoma: A Problem of Anchoring Bias and Confounding Immunohistochemistry (p40) Staining

We report a case of an adamantinoma demonstrating heretofore unreported immunohistochemical expression of p40 that was interpreted to be a metastatic squamous cell carcinoma on the biopsy. This misdiagnosis can be attributed to anchoring bias from the submitted clinical information and this unreported clinical phenomenon. We discuss the nature of anchoring bias and the breadth and depth of its influence on the practice of pathology, as well as document the heretofore unreported expression of p40 by an adamantinoma.
Source: Pathology Case Reviews - Category: Pathology Tags: Case Reviews Source Type: research