Focal cortical dysplasia – relevant for seizures in Phelan McDermid syndrome?

Phelan McDermid syndrome (PMS) is a neurogenetic disorder characterized by global developmental delay, intellectual disability, absent or severely impaired language, and hypotonia, combined with a broad spectrum of other clinical symptoms and variable dysmorphic features.Epilepsy is present or develops in a substantial number of these patients but it is origin is still unclear, especially whether there are perhaps subtle malformations in this developmental disorder that have so far not been identified by conventional MRI.
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Research Letter Source Type: research