Negative Symptoms and Functioning in Youth at Risk of Psychosis: A Systematic Review and Meta-analysis

The objective of this systematic review is to summarize the relationship between negative symptoms and functioning in CHR samples. Method Electronic databases CINAHL, EBM, Embase, MEDLINE, and PsycINFO were searched from inception. Studies were selected if they included any study that reported a relationship between negative symptoms and functioning in youth at clinical high risk (CHR). The correlation coefficient r was converted to Cohen’s d, and all random-effects meta-analyses were performed using the transformed values. Results Forty-one studies met the inclusion criteria, including a total of 4574 individuals at CHR for psychosis. Negative symptom total scores were significantly associated with poorer global functioning (d, −1.40; 95% CI, −1.82 to −0.98; I2 = 79.4%; p
Source: Harvard Review of Psychiatry - Category: Psychiatry Tags: Reviews Source Type: research