Inference about causation from examination of familial confounding (ICE FALCON): a model for assessing causation analogous to Mendelian randomization

ConclusionsThere are conceptual similarities between ICE FALCON and MR, but empirically they are giving similar conclusions with possibly more information per subject from ICE FALCON. ICE FALCON can be applied to circumstances in which MR cannot be applied, such as when there is no a priori genetic knowledge and/or data available to create a valid instrumental variable, or when the assumptions underlying MR analysis are suspect. ICE FALCON could provide insights into causality for a wide range of public health questions.
Source: International Journal of Epidemiology - Category: Epidemiology Source Type: research