Synergistic induction of IL-23 by TNF α, IL-17A, and EGF in keratinocytes.
In this study, we demonstrated that IL-23 production is induced by a combination of TNFα and IL-17A in human keratinocytes. Additionally, this IL-23 induction by TNFα and IL-17A is further increased in psoriatic keratinocytes and is enhanced by EGFR signaling. Although IL-23 is also robustly induced by toll-like receptor agonists in dendritic cells and macrophages, IL-23 expression in these cell types is not regulated by TNFα, IL-17A, and EGFR signaling. Given that IL-23 is essential for maintaining Th17 activation, IL-23 induction by TNFα, IL-17A, and EGF in keratinocytes could play an important pathological role in psoriasis pathogenesis as well as the cutaneous rash associated with EGFR inhibition therapy.
PMID: 33153894 [PubMed - as supplied by publisher]
Source: Cytokine - Category: Molecular Biology Authors: Ehst B, Wang Z, Leitenberger J, McClanahan D, De La Torre R, Sawka E, Ortega-Loayza AG, Strunck J, Greiling T, Simpson E, Liu Y Tags: Cytokine Source Type: research