Bugs as Drugs: The Role of Microbiome in Cancer Focusing on Immunotherapeutics

The microorganisms living on and in the human body including bacteria, viruses, fungi, protozoa and other microbes, as well as their collective genomes and metabolic products constitute the human microbiome. The field of microbiome research in cancer has grown substantially over the past decade, with a nearly 46-fold increase in publications from 2009 to 2019 (37 to 1727 articles) based on PubMed using the search terms “microbiome” and “cancer”. The bacterial component of the intestinal microbiome has gained specific interest in oncology as accumulating evidence indicates a strong association with host anticancer immune responses, influencing the efficacy and toxicity of immune-checkpoint inhibitors (ICI) (1-6).
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Hot Topic Source Type: research