Compressive force strengthened the pro-inflammatory effect of zoledronic acid on il-1 ß stimulated human periodontal fibroblasts

ConclusionsBiomechanical stress might trigger a pro-inflammatory potential of BP further enhanced in the presence of an inflammatory pre-stimulation.Clinical relevanceTo prevent excessive host inflammatory responses, occlusal overloading and mechanical stress due to orthodontic treatment should be avoided in BP patients with untreated periodontitis.
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research