Regulatory T Cells in the Tumor Microenvironment.

Regulatory T Cells in the Tumor Microenvironment.
Adv Exp Med Biol. 2020;1273:105-134
Authors: Dadey RE, Workman CJ, Vignali DAA
Abstract
Regulatory T cells (Tregs) are an immunosuppressive subpopulation of CD4+ T cells that are endowed with potent suppressive activity and function to limit immune activation and maintain homeostasis. These cells are identified by the hallmark transcription factor FOXP3 and the high-affinity interleukin-2 (IL-2) receptor chain CD25. Tregs can be recruited to and persist within the tumor microenvironment (TME), acting as a potent barrier to effective antitumor immunity. This chapter will discuss [i] the history and hallmarks of Tregs; [ii] the recruitment, development, and persistence of Tregs within the TME; [iii] Treg function within TME; asnd [iv] the therapeutic targeting of Tregs in the clinic. This chapter will conclude with a discussion of likely trends and future directions.
PMID: 33119878 [PubMed - as supplied by publisher]

Source: Advances in Experimental Medicine and Biology - October 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research