[Pathogenic role leukotriene B4 in lung injury induced by lung-protective mechanical ventilation in rabbits].

CONCLUSIONS: LPMV can induce LTB4 overproduction to down-regulate cAMP/PKA and Rap1 signaling pathways in the lungs of rabbits, which results in lung hyper-permeability and inflammation. Bestatin can inhibit LTB4 production in the lungs to protect against LPMV-induced lung hyper-permeability and inflammation.
PMID: 33118515 [PubMed - in process]

Source: Journal of Southern Medical University - October 30, 2020 Category: Universities & Medical Training Authors: Yuan L, Li J, Yang Y, Guo X, Liu X, Li L, Zhu X, Liu R Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research