Study Updates Risks for Breast Cancer Associated With HRT

THURSDAY, Oct. 29, 2020 -- Long-term use of estrogen-only and combined estrogen and progestogen hormone replacement therapy (HRT) is associated with an increased risk for breast cancer, according to a study published online Oct. 28 in The BMJ. Yana...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news

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In this issue of the Journal, a group of distinguished Nordic researchers, led by Anne Helene Garde and including four of our Associated Editors, present a discussion paper that originated from a workshop and provides detailed recommendations on night shift work (1). The recommendations are very clear: to protect workers ’ health, night shift schedules should have: (i) ≤3 consecutive night shifts; (ii) shift intervals of ≥11 hours; and (iii) ≤9 hours shift duration. For pregnant women, night work should be limited to one shift per week. The authors acknowledge that under circumstances allowing better possibi...
Source: Scandinavian Journal of Work, Environment and Health - Category: Occupational Health Tags: Editorial Source Type: research
Introduction: Lobular breast cancer is less common that ductal carcinoma, and can be more difficult to diagnose by both physical examination and mammography. Previous studies have shown a general increase in lobular breast cancer rates over the 1980s-1990s, however this was during a time when the use of combined hormone replacement therapy (CHRT) – a known risk factor for breast cancer – was increased. As CHRT use has declined since the mid 2000s, this study endeavoured to evaluate current trends in the incidence of invasive lobular carcinoma (ILC) in women diagnosed with breast cancer, and to describe the 5-, ...
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: POSTERS A: Local Regional Treatment – Surgery Source Type: research
Selective activation of the estrogen receptor-β by the polysaccharide from Cynanchum wilfordii alleviates menopausal syndrome in ovariectomized mice. Int J Biol Macromol. 2020 Sep 26;: Authors: Lee E, Jang M, Lim TG, Kim T, Ha H, Lee JH, Hong HD, Cho CW Abstract The menopausal syndrome caused by rapid changes in hormone levels greatly influences the quality of life of women. Though hormone replacement therapy (HRT) is widely used to treat the menopausal syndrome, it exhibits many side effects, including the risk of thrombosis, cardiovascular diseases, and increased incidence of breast cancer; thu...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
uet D Abstract Breast cancer is the most frequently diagnosed cancer in women and the first cause of cancer death in France. Among the different subtypes of breast cancer, the predominant form is characterized by positive hormone receptors (more than 70% of breast cancers). Hormone therapy thus plays a key role in the strategy of management of these cancers both in adjuvant and metastatic situations. The two types of adjuvant hormone therapy used are selective estrogen receptor modulators and aromatase inhibitors. Fulvestrant, an anti-estrogen, is used alone or in combination with other molecules in metastatic sit...
Source: Bulletin du Cancer - Category: Cancer & Oncology Authors: Tags: Bull Cancer Source Type: research
Abstract Long non-coding RNAs (lncRNAs) have been vastly investigated for their critical roles in the pathogenesis of breast cancer. Yet, the expression pattern and clinical significance of three lncRNAs namely CTBP1AS2, LINC-ROR and SPRY4-IT1 in breast cancer are not completely clarified. In the present investigation, we assessed expression of these lncRNAs in breast cancer tissues and paired non-cancerous specimens from the same patients using quantitative real time PCR. Notably, expression of CTBP1AS2, LINC-ROR and SPRY4-IT1 were upregulated in breast cancer tissues compared with non-cancerous tissues (ER = 17.62, P value
Source: Experimental and Molecular Pathology - Category: Pathology Authors: Tags: Exp Mol Pathol Source Type: research
ConclusionScreen-detected women and women who had mammograms biennially had lower odds of being diagnosed with high-severity breast cancer, which highlighted the benefit of regular breast cancer screening. Women in subgroups who are more likely to have more severe cancers should be particularly encouraged to participate in regular mammography screening.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
SummaryThe San Antonio Breast Cancer Summit is one of the most important meetings worldwide for physicians who treat breast cancer. As traveling there is always somewhat of an adventure due to the distance and the time of the year (winter) and access is not easy for all physicians, the goal of this article is to provide an overview of the presentations dealing with hormone-receptor-positive breast cancer, capecitabine, prevention, and hormone replacement therapy. Data and results should positively influence daily practice.
Source: Memo - Magazine of European Medical Oncology - Category: Cancer & Oncology Source Type: research
A new study, from UCLA Medical Center, women who had had their uteruses removed and were taking HRT had a 25% lower risk of breast cancer than women given a placebo.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionOur study contributes to the descriptive prevalence of some known risk factors in Indian breast cancer patients.
Source: The Journal of Obstetrics and Gynecology of India - Category: OBGYN Source Type: research
ConclusionsEpidemiological evidence is rather consistent suggesting that there is a positive association between HRT use and MD with the highest increase in MD among current users, and CEP users. Our results suggest that due to increase in MD and masking effect, current E  + P users may require additional screening procedures, shorter screening intervals, or using advanced imaging techniques.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
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