Molecules, Vol. 25, Pages 4870: Topical Wound Healing Activity of Myricetin Isolated from Tecomaria capensis v. aurea

Molecules, Vol. 25, Pages 4870: Topical Wound Healing Activity of Myricetin Isolated from Tecomaria capensis v. aurea Molecules doi: 10.3390/molecules25214870 Authors: Abdelsamed I. Elshamy Naglaa M. Ammar Heba A. Hassan Walaa A. El-Kashak Salim S. Al-Rejaie Ahmed M. Abd-ElGawad Abdel-Razik H. Farrag Wounds and burn injury are major causes of death and disability worldwide. Myricetin is a common bioactive flavonoid isolated naturally from the plant kingdom. Herein, a topical application of naturally isolated myricetin from the shoots of Tecomaria capensis v. aurea on excisional wound healing that was performed in albino rats. The wounded rats were treated every day with 10 and 20% myricetin for 14 days. During the experiment, the wound closure percentage was estimated at days 0, 7, and 14. Effects of myricetin on the inflammatory cytokines (tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and cluster of differentiation 68 (CD68) in the serum were evaluated using immunosorbent assay kits. The percentage of wound closure and contraction was delayed in wounded rats (67.35%) and was remarkably increased after treatment of wounded rats with myricetin; the treatment with 20% myricetin was the most potent (98.76%). Histological findings exhibited that 10% myricetin caused the formation of a large area of scarring at the wound enclosure and stratified squamous epithelium without the formation of papilla...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research