Prevalence and Effect of Genetic Risk of Thrombo-embolic Disease in Inflammatory Bowel Disease.

The largest cause of mortality in patients with inflammatory bowel disease (IBD) remains thrombo-embolic disease (TED). Recent reports have demonstrated that both monogenic and polygenic factors contribute to TED and 10% of ‘healthy’ subjects are genetically at high risk for TED. Our aim was to utilize whole exome sequencing (WES) and genome-wide genotyping to determine the proportion of IBD patients genetically at risk for TED and investigate the effect of genetic risk of TED in IBD.

Source: Gastroenterology - October 21, 2020 Category: Gastroenterology Authors: Takeo Naito, Gregory J. Botwin, Talin Haritunians, Dalin Li, Shaohong Yang, Michelle Khrom, Jonathan Braun, NIDDK IBD Genetics Consortium, Lisa Abbou, Emebet Mengesha, Christine Stevens, Atsushi Masamune, Mark Daly, Dermot P.B. McGovern Source Type: research