3-Mercaptopyruvate sulfurtransferase: an enzyme at the crossroads of sulfane sulfur trafficking.

3-Mercaptopyruvate sulfurtransferase: an enzyme at the crossroads of sulfane sulfur trafficking. Biol Chem. 2020 Oct 01;: Authors: Pedre B, Dick TP Abstract 3-Mercaptopyruvate sulfurtransferase (MPST, also annotated as 3-MST or MST) catalyzes the desulfuration of 3-mercaptopyruvate (3MP) to generate an enzyme-bound hydropersulfide. Subsequently, MPST transfers the persulfide's outer sulfur atom to proteins or small molecule acceptors. MPST activity is known to be involved in hydrogen sulfide (H2S) generation, tRNA thiolation, protein urmylation and cyanide detoxification. Tissuespecific changes in MPST expression correlate with ageing and the development of metabolic disease. Deletion and overexpression experiments suggest that MPST contributes to oxidative stress resistance, mitochondrial respiratory function and the regulation of fatty acid metabolism. However, the role and regulation of MPST in the larger physiological context remain to be understood. PMID: 33055309 [PubMed - as supplied by publisher]
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research