Recent advances in biocatalytic derivatization of L-tyrosine.

Recent advances in biocatalytic derivatization of L-tyrosine.
Appl Microbiol Biotechnol. 2020 Oct 17;:
Authors: Tan X, Song W, Chen X, Liu L, Wu J
Abstract
L-Tyrosine is an aromatic, polar, non-essential amino acid that contains a highly reactive α-amino, α-carboxyl, and phenolic hydroxyl group. Derivatization of these functional groups can produce chemicals, such as L-3,4-dihydroxyphenylalanine, tyramine, 4-hydroxyphenylpyruvic acid, and benzylisoquinoline alkaloids, which are widely employed in the pharmaceutical, food, and cosmetics industries. In this review, we summarize typical L-tyrosine derivatizations catalyzed by enzymatic biocatalysts, as well as the strategies and challenges associated with their production processes. Finally, we discuss future perspectives pertaining to the enzymatic production of L-tyrosine derivatives.Key points• Summary of recent advances in enzyme-catalyzed L-tyrosine derivatization.• Highlights of relevant strategies involved in L-tyrosine derivatives biosynthesis.• Future perspectives on industrial applications of L-tyrosine derivatization.
PMID: 33067683 [PubMed - as supplied by publisher]

Source: Applied Microbiology and Biotechnology - October 17, 2020 Category: Microbiology Authors: Tan X, Song W, Chen X, Liu L, Wu J Tags: Appl Microbiol Biotechnol Source Type: research