Reduction of breast cancer mortality associated with mammography screening: a modelling study using population-based data from 2 French d épartements.

Reduction of breast cancer mortality associated with mammography screening: a modelling study using population-based data from 2 French départements. Am J Epidemiol. 2020 Oct 12;: Authors: Seigneurin A, Exbrayat C, Molinié F, Croisier L, Poncet F, Berquet K, Delafosse P, Colonna M Abstract Meta-analyses of randomized controlled trials that started from 1963 to 1991 reported a decrease of breast cancer mortality associated with mammography screening. However, the effectiveness of population based screening programmes conducted nowadays may have changed, due to the better effectiveness of treatments for late stage cancers and the better diagnostic performance of mammography. The main objective of this study was to predict the reduction of breast cancer mortality associated with mammography screening in the French current setting. We compared breast cancer mortality in 2 simulated cohorts of women, which differed from each other solely by a 70% biennial participation in screening from 50 to 74 years old. The micro-simulation model used for predictions was calibrated with incidence rates of breast cancer by stage that were observed in Isère and Loire-Atlantique départements, France in 2007-2013. The model predicted a decrease of breast cancer mortality associated with mammography screening of 18% (95%CI: 5% - 31%) and 17% (95%CI: 3% - 29%), for models calibrated with data from Isère and Loire-Atlantique départements, respectively. ...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research