Acacienone, a terpenoid-like natural product having an unprecedented C20 framework isolated from Acacia mangium leaves

AbstractA novel C20 natural product, acacienone (1), was isolated from the leaves ofAcacia mangium collected in Bangladesh. The structure of compound1 was elucidated by spectral studies and X-ray crystallographic analysis. Acacienone (1) possesses a terpenoid-related tetracyclic framework containing 20 carbons with biogenetically unusual structural features: (i) vicinal C1-branches at the C-3 and C-4 positions in the A ring, and (ii) a cyclopentenone D ring in an androsterone-like assembly, lacking a methyl group at the C-13 position.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research