Comparatively Evaluating the Role of Herb Pairs Containing Angelicae Sinensis Radix in Xin-Sheng-Hua Granule by Withdrawal Analysis.

Comparatively Evaluating the Role of Herb Pairs Containing Angelicae Sinensis Radix in Xin-Sheng-Hua Granule by Withdrawal Analysis. Evid Based Complement Alternat Med. 2020;2020:9456350 Authors: Pang HQ, Xu DQ, Tang YP, Zhou GS, Xu HQ, Jin Y, Zhu ZH, Shi XQ, Yue SJ, Chen YY, Huang SL, Duan JA Abstract The present study aims to investigate the roles of herb pairs containing Angelicae Sinensis Radix (Danggui) in Xin-Sheng-Hua Granule (XSHG) on hemolytic and aplastic anemia (HAA) mice. HAA model mice were induced by acetyl phenylhydrazine and cyclophosphamide; then the samples of XSHG and its decomposed recipes (DY, DC, DT, DH, DJ, and DZ) were orally administrated to these mice. Indicators of peripheral blood routine, organ index, and ATPase activities were tested. Moreover, the main effective components in these samples were also analyzed by UHPLC-TQ-MS/MS. Clear separation between the control and model groups from score plot of principal component analysis (PCA) was easily seen, indicating that HAA model was successfully conducted. Afterwards, relative distance calculation method between dose groups and control group from PCA score plot was adopted to evaluate the integrated effects of hematinic function of different samples. And the orders of hematinic effects were as follows: XHSG > DJ > DT > DZ > DH > DC > DY. Further analysis of these samples by UHPL...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

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Cytomegalovirus (CMV) infection is a major infectious complication following an allogeneic hematopoietic stem cell transplantation (allo-HSCT). CMV end-organ disease is a significant cause of morbidity and mortality following an allo-HSCT despite advances in the early diagnosis and managements of CMV infection (1-5). Early detection of CMV reactivation through CMV antigenemia or polymerase chain reaction (PCR) assay and the use of preemptive antiviral therapy using ganciclovir (GCV), valganciclovir (VGCV), or foscarnet (FOS) decreased the incidence of CMV end-organ disease within the first 100 days after allo-HSCT to
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Contributors : Syed Mian ; Shahram KordastiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOur report demonstrates that the dominant Treg population in AA are FasL resistant but do not respond to low concentration of IL-2, leading to immune dysregulation. And In vitro expanded AA Tregs are stable, functional and highly express p-BCL-2 with therapeutic potential in AA patients
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
ConclusionVery long term survivors after AA are those with stable hematopoietic recovery.
Source: Annals of Hematology - Category: Hematology Source Type: research
Abstract The article High-Dose Aluminum Exposure Further Alerts Immune Phenotype in Aplastic Anemia Patients, written by Yao Zuo, Xiang Lu, Xiaochao Wang, Suren R. Sooranna, Liju Tao, Shiqiang Chen, Hongwen Li, Dan Huang, Guanye Nai, Hong Chen, Chunfeng Pan, Caihong Huang and Yanmin Pang. PMID: 33015744 [PubMed - as supplied by publisher]
Source: Biological Trace Element Research - Category: Biology Authors: Tags: Biol Trace Elem Res Source Type: research
(University of Montreal) Developed in Canada, the UM171 molecule was used in a blood transplant by a Montreal medical team on a young man suffering from severe aplastic anemia, an autoimmune disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Authors: Ren X, Li X, Huo J, You Y, Huang J, Shao Y, Ge M, Huang Z, Zhang J, Wang M, Jin P, Nie N, Zheng Y Abstract Objectives: To clear the obscure conclusion on the prediction value of paroxysmal nocturnal haemoglobinuria (PNH) clones in severe aplastic anaemia (SAA) patients treated with immunosuppressive therapy (IST). Methods: We retrospectively analyzed 219 consecutive SAA patients treated with IST from October 2008 to October 2015 and evaluated the haematological responses to IST. Results: The presence of a PNH clone was detected in 55 (25.1%) patients prior to IST [37/88 by flow cytometry (FCM) and 18/131 b...
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
Conditions:   Aplastic Anemia;   Bone Marrow Failure Syndrome;   Dyskeratosis Congenita Interventions:   Drug: Anti-Thymocyte Globulin (Rabbit);   Drug: Fludarabine;   Drug: Cyclophosphamide;   Drug: Mesna;   Drug: G-CSF;   Radiation: Total Lymphoid Irradiation (TLI);   Device: CliniMACS;   Biological: HPC, A Infusion;   Biological: CD45RA-depleted DLI Sponsor:   St. Jude Children's Research Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract We retrospectively analyzed nationwide records of 163 Fanconi anemia (FA) patients [aplastic anemia (AA), n = 118; myelodysplastic syndrome (MDS), n = 30; acute leukemia, n = 15] who underwent first allogeneic hematopoietic stem cell transplantation (HSCT) between 1987 and 2015 in Japan. An alternative donor was used in 119 (73%) patients, and 160 (98%) patients received a non-T-cell-depleted graft. With an 8.7-year median follow-up, 5-year overall survival (OS) was 81%. The 5-year OS was significantly higher in AA patients than in MDS and acute leukemia patients ...
Source: International Journal of Hematology - Category: Hematology Authors: Tags: Int J Hematol Source Type: research
While cytokine storm develops in a minority of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, novel treatment approaches are desperately needed for those in whom it does. Tocilizumab, an interleukin-6 receptor antibody, has been utilized for the treatment of cytokine storm in a number of severe inflammatory conditions, including in patients with severe coronavirus disease 2019 (COVID-19). Here, we present the first published case utilizing this therapy in a patient with underlying immunodeficiency. Our patient with aplastic anemia developed cytokine storm due to COVID-19 manifested by...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Noun P, Ibrahim A, Hodroj MH, Bou-Fakhredin R, Taher AT Abstract INTRODUCTION: Many patients with inherited or acquired benign hematological disorders are at increased risk of developing severe complications from COVID-19. These patients, therefore, require specific advice regarding isolation and changes to their usual treatment schedules. Their disease can also be associated with significant burden, and they necessitate life-long and regular access to therapy, and regular follow-up consultations and hospital visits. The current COVID-19 pandemic is therefore presenting many challenges for these patients, ...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
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