Force dependent effects of chronic overuse on fibrosis-related genes and proteins in skeletal muscles.

CONCLUSIONS: Our results suggest that there is steady-state transcription of fibrogenic genes in muscles with established fibrosis, implying that post-transcriptional processes are responsible for the increased protein levels of fibrotic factors during muscle overuse conditions. We hypothesize that targeting such pathways represents a valid approach to treat overuse injury. Alternatively, FGF2 gene expression may represent a valid target for therapy.
PMID: 33030055 [PubMed - as supplied by publisher]

Source: Connective Tissue Research - October 9, 2020 Category: Research Tags: Connect Tissue Res Source Type: research