ASAP Aptamer Generated by Cell-SELEX for Specific Targeting of Human Glioma Cells

ACS Applied Materials&InterfacesDOI: 10.1021/acsami.0c11878
Source: ACS Applied Materials and Interfaces - Category: Materials Science Authors: Source Type: research

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Conditions:   Brain Metastases;   Cancer;   Gliomas;   Glioblastoma Interventions:   Drug: F18 Fluciclovine;   Other: Standard of Care Sponsor:   M.D. Anderson Cancer Center Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Immunotherapy has changed the landscape of treatments for advanced disease in multiple neoplasms. More and more patients are long survivors from a metastatic disease. Most recently, the extension of indications and evidence of efficacy in early disease settings, such as the adjuvant and neoadjuvant setting in breast cancer, lung cancer, glioma, and gastric cancer, places more attention on what happens to patients who survive cancer. In particular, we evaluated what happens in young patients, a population in whom some immune-related effects are still poorly described. Immunotherapy is already a reality in early disease sett...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
This article reviews recent advances in the use of standard and advanced imaging techniques for diagnosis and treatment of central nervous system (CNS) tumors, including glioma and brain metastasis. Following the recent transition from a histology-based approach in classifying CNS tumors to one that integrates histology with the molecular information of tumor, the approaches for imaging CNS tumors have also been adapted to this new framework. Some challenges related to the diagnosis and treatment of CNS tumors, such as differentiating tumor from treatment-related imaging changes, require further progress to implement advan...
Source: Hematology/Oncology Clinics of North America - Category: Cancer & Oncology Authors: Source Type: research
Gliomas are the most common primary tumors of the central nervous system. Due to the existence of the blood-brain barrier and its unique regional immune characteristics, the study of the immune microenvironment of gliomas is particularly important. Glioma stem cells are an important cause of initiating glioma, promoting tumor progression and leading to tumor recurrence. Immunotherapeutic strategies targeting glioma stem cells have become the focus of current research. This paper will focus on the research progress of glioma stem cells in the immune microenvironment of glioma to provide the basis for the immunotherapy of glioma.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
u The behavior of lower-grade glioma (LGG) is changing over time, spontaneously, and in reaction to treatments. First, due to genomic instability and clonal expansion, although LGG progresses slowly during the early period of the disease, its growth velocity will accelerate when this tumor will transform to a higher grade of malignancy. Furthermore, its pattern of progression may change following therapy, e.g., by switching from a proliferative towards a more diffuse profile, in particular after surgical resection. In parallel to this plasticity of the neoplasm, the brain itself is constantly adapting to the tumor and ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
AbstractApigenin, a natural flavonoid compound present in a variety of edible plants and health foods, has an anti-tumor effect and inhibits hypoxia inducible factor-l α (HIF-1α) expression in hypertrophic cardiac tissues. However, whether or not apigenin has a radiosensitization effect on glioma stem cells (GSCs) is unknown. Our present study aimed to investigate the effect of apigenin and its possible mechanisms. The human GSCs SU3 and its radioresistance line SU3-5R were treated with apigenin, radiation, or their combination, and the cell proliferation, migration, colony formation, and intracellular lactic a...
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research
Early evidence suggests that an oncolytic virus engineered to kill malignant gliomas may improve survival.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
CONCLUSION: 3D ASL and DSC PWI are consistent in evaluating blood flow in brain tumors and can accurately evaluate brain tumors perfusion.PMID:34549723 | DOI:10.12122/j.issn.1673-4254.2021.08.23
Source: Journal of Southern Medical University - Category: Universities & Medical Training Authors: Source Type: research
Nan Fang Yi Ke Da Xue Xue Bao. 2021 Aug 20;41(8):1171-1176. doi: 10.12122/j.issn.1673-4254.2021.08.07.ABSTRACTOBJECTIVE: To investigate neuregulin 2 (NRG2) expression in gliomas and its role in glioma development.METHODS: We compared the expression levels of NRG2 and glial fibrillary acidic protein (GFAP) in low-grade glioma (LGG) and glioblastoma multiforme (GBM) with those in normal control samples using GEPIA database.The correlation between NRG2 and GFAP expression and their association with the overall survival of patients with LGG and GBM were analyzed.Immunohistochemical staining was used to detect NRG2 protein expr...
Source: Journal of Southern Medical University - Category: Universities & Medical Training Authors: Source Type: research
CONCLUSIONS: LY3200882 as monotherapy and combination therapy was safe and well tolerated with preliminary antitumor activity observed in PC. Further studies to evaluate the efficacy of LY3200882 with gemcitabine and nab-paclitaxel in advanced PC are warranted.PMID:34548321 | DOI:10.1158/1078-0432.CCR-21-1504
Source: Cell Research - Category: Cytology Authors: Source Type: research
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