Tuberculosis related stigma in India: roadblocks and the way forward.

Tuberculosis related stigma in India: roadblocks and the way forward. Expert Rev Respir Med. 2020 Oct 06;: Authors: Thomas BE, Stephen A PMID: 33021117 [PubMed - as supplied by publisher]
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

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[MBC] The 2021 World Health Organisation Global Tuberculosis Report has revealed that for the first time in over a decade TB deaths have increased globally because of reduced access to TB diagnosis and treatment in the face of the COVID-19 pandemic.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
Source: Journal of Inflammation Research - Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
CONCLUSION: In the 46 patients who entered the voluntary extension of this phase 2 study, clinical benefit in global and organ-specific SLE-activity measures was observed with ustekinumab through 2years with no new or unexpected safety findings. clinicaltrials.gov: NCT02349061.PMID:34853089 | DOI:10.3899/jrheum.210805
Source: J Rheumatol - Category: Rheumatology Authors: Source Type: research
In 2001, U.N. estimates suggested 150 million people would be infected with H.I.V. by 2021. That preceded an ambitious global campaign to curb the virus. How well did it work?
Source: NYT Health - Category: Consumer Health News Authors: Tags: Acquired Immune Deficiency Syndrome Drugs (Pharmaceuticals) Global Fund to Fight AIDS, Tuberculosis and Malaria President ' s Emergency Plan for AIDS Relief UNAIDS internal-open-access Source Type: news
Mycobacterium tuberculosis (Mtb) bacilli readily aggregate. We previously reported that Mtb aggregates lead to phagocyte death and subsequent efficient replication in the dead infected cells. Here, we examined the transcriptional response of human monocyte derived macrophages to phagocytosis of aggregated Mtb relative to phagocytosis of non-aggregated single or multiple bacilli. Infection with aggregated Mtb led to an early upregulation of pro-inflammatory associated genes and enhanced TNFα signaling via the NFκB pathway. These pathways were significantly more upregulated relative to infection with single or mu...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Abstract A series of novel palladium(II) and nickel(II) complexes of multifunctionalized aroylaminocarbo-N-thioylpyrrolinates were synthesized and characterized by analytical and spectroscopic techniques. The biological properties of the freshly prepared compounds were screened against S. aureus, B. subtilis, A. hydrophila, E. coli, and A. baumannii bacteria and antituberculosis activity against M. tuberculosis H37Rv strains. Also, the antifungal activity was studied against C. albicans, C. tropicalis, and C. glabrata standard strains. A deep conformational survey was monitored using DFT calculations with the aim to explai...
Source: Beilstein Journal of Organic Chemistry - Category: Chemistry Authors: Tags: antituberculosis bidentate ligands DFT nickel palladium Full Research Paper Source Type: research
BackgroundTuberculous pleural effusion (TPE) is one of the most common forms of extrapulmonary tuberculosis (Tb). Patients with TPE or malignant pleural effusions (MPE) frequently have a similar lymphocytic pleural fluid profile. Since the etiology of PE in various diseases is different, identifying the cellular components may provide diagnostic clues for understanding the pathogenesis.ObjectiveWe determined the frequency of T helper (Th) subtypes in the PEs for differentiation of Tb and non-Tb patients.MethodsThirty patients with TPE, 30 patients with MPE, 14 patients with empyema (EMP), and 14 patients with parapneumonic...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Peritoneal tuberculosis is difficult to diagnose as it may mimic peritoneal carcinomatosis, which has similar symptomatology. We sought to determine the diagnostic accuracy of computed tomography in differentiating peritoneal tuberculosis versus peritoneal carcinomatosis.
Source: Clinical Imaging - Category: Radiology Authors: Tags: Body Imaging Source Type: research
This study aimed to estimate the costs and incremental cost-effectiveness of two community-based tuberculosis (TB) active case-finding (ACF) strategies in Cambodia. We also assessed the number needed to screen and test to find one TB case. Program and national TB notification data from a quasi-experimental study of a cohort of people with TB in 12 intervention operational districts (ODs) and 12 control ODs between November 2018 and December 2019 were analyzed. Two ACF interventions (ACF seed-and-recruit (ACF SAR) model and one-off roving (one-off) ACF) were implemented concurrently. The matched control sites included PCF o...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Condition:   Tuberculosis Intervention:   Sponsor:   Centre for Infectious Disease Research in Zambia Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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