The skin doesn't lie: a case of dermatitis herpetiformis in the setting of refractory coeliac disease.

The skin doesn't lie: a case of dermatitis herpetiformis in the setting of refractory coeliac disease. G Ital Dermatol Venereol. 2020 Oct 05;: Authors: Quintarelli L, Corrá A, Maglie R, Antiga E, Caproni M PMID: 33016667 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research

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In this study we investigated whether patients with DH and CD (mean age for both 49 years) have circulating autoantibodies against BP180, the major BP autoantigen. ELISA tests showed that only a few DH (3/46) and CD (2/43) patients had BP180-NC16A IgG autoantibodies. Immunoblotting found that more than half of the DH samples contained IgG autoantibodies against full-length BP180. Epitope mapping with 13 fusion proteins covering the BP180 polypeptide revealed that in DH and CD patients, IgG autoantibodies did not target the NC16A or other epitopes typical of BP but recognized other intracellular and mid-extracellular region...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Atopic dermatitis (AD) is an eczematous inflammatory skin disease that confers an increased risk for several atopic, somatic and psychiatric comorbidities (Brunner et al, 2017, Kauppi et al, 2019). Recent epidemiological data suggests that AD patients are at risk for several autoimmune diseases (Narla and Silverberg, 2019). Celiac disease (CD) is an autoimmune disease, in which dietary gluten intake induces enteropathy (Collin et al, 2017). Dermatitis herpetiformis (DH) is an extraintestinal manifestation of CD presenting with intensely pruritic vesicles on specific skin areas (Collin et al, 2017).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research
Dermatitis herpetiformis (DH), an itchy blistering skin condition, is considered an extraintestinal manifestation of celiac disease. Both manifestations are driven by the ingestion of dietary gluten, which induces an inflammatory response hallmarked by B- and T-cell activation (Collin et  al., 2017; du Pré and Sollid, 2015). In celiac disease, the gluten-induced T-cell response has been assessed by various means, including an oral three-day wheat challenge coupled with an IFN-γ enzyme-linked immunospot (ELISpot) assay (Anderson et al., 2000; Camarca et al., 2012; Hardy et al., 2015; Tye-Din...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letter to the Editor Source Type: research
Dermatitis herpetiformis (DH), an itchy blistering skin condition, is considered an extraintestinal manifestation of celiac disease. Both manifestations are driven by the ingestion of dietary gluten, which induces an inflammatory response hallmarked by B and T cell activation (Collin et al., 2017; du Pr é and Sollid 2015). In celiac disease, the gluten-induced T cell response has been assessed by various means, including an oral three-day wheat challenge coupled with an interferon-γ (IFN-γ) enzyme-linked immunospot (ELISpot) assay (Anderson et al., 2000; Tye-Din et al., 2010a; Camarca et al., 20 12; Hardy et al., 2015).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research
Abstract Dermatitis herpetiformis (DH) is an autoimmune skin disease that causes itchy, blistering rash, typically on the elbows, knees and buttocks. DH and coeliac disease share the same genetic background, gluten-dependent enteropathy and antibody response against tissue transglutaminase. DH is currently considered a cutaneous manifestation of coeliac disease, and the prevailing hypothesis is that DH develops as a late manifestation of subclinical coeliac disease. The incidence of DH is decreasing contemporarily with the increasing incidence of coeliac disease. The IgA immune response in DH skin is directed agai...
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
Authors: Dmochowski M, Gornowicz-Porowska J, Bowszyc-Dmochowska M Abstract This mini-review presents an update on the direct immunofluorescence (DIF) for diagnosing dermatitis herpetiformis. The DIF of uninvolved, perilesional skin is a crucial laboratory procedure in diagnosing dermatitis herpetiformis (DH). IgA deposits at the dermal-epidermal junction (DEJ) of perilesional skin with DIF can also be found in coeliac patients with inflammatory skin diseases different from DH. In certain patients presenting with the rash resembling DH, the deposition of exclusively C3 at DEJ can be found. The term "granular C3...
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
Conditions:   Alopecia Areata;   Depressive Episode;   Recurrent Depressive Disorder;   Anxiety Disorders;   Atopic Dermatitis;   Allergic Rhinitis;   Asthma;   Crohn Disease;   Ulcerative Colitis;   Pernicious Anemia;   Type 1 Diabetes;   Hashimoto Thyroiditis;   Graves Disease;   Rheumatoid Arthritis;   Psoriatic Arthritis;   Ankylosing Spondylitis;   Systemic Lupus Erythematosus;   Polymyalgia Rheumatica;   Sjogren's Syndro...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsThis case demonstrates the simultaneous presentation of multiple conditions. Oral biopsy revealed a solitary focus of granulomatous inflammation, indicative of orofacial granulomatosis. However, the biopsied lesion was also unusual in that inflammation extended into the epithelium, a relatively unusual feature for a granulomatous inflammatory disease and a pattern more commonly seen in vesiculobullous eruptions. Because this patient's CD was well controlled, it is difficult to believe that these oral lesions were associated with CD activity. One reasonable assumption is that the long-time treatment of the patien...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Authors: Noori E, Kazemi B, Bandehpour M, Zali H, Khalesi B, Khalili S Abstract Coeliac disease (CD) is a chronic autoimmune disease that is characterized by malabsorption in sensitive individuals. CD is triggered by the ingestion of grains containing gluten. CD is concomitant with several other disorders, including dermatitis herpetiformis, selective IgA deficiency, thyroid disorders, diabetes mellitus, various connective tissue disorders, inflammatory bowel disease, and rheumatoid arthritis. The advent of high throughput technologies has provided a massive wealth of data which are processed in various omics scale...
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
CONCLUSIONS: At adolescence, both Crohn's disease and ulcerative colitis are associated with multiple comorbidities, not limited to autoimmune disorders. PMID: 31801156 [PubMed - as supplied by publisher]
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
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