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In order to promote precision medicine, Kolmert et al (Am J Respir Crit Care Med. 2020 Jul 15. https://doi.org/10.1164/rccm.201909-1869oc) characterized expression of urinary lipid mediators in patients with type 2 asthma. Levels of multiple types of eicosanoids, including leukotriene E4 (LTE4) and prostaglandin D2, positively correlated with severity of asthma and type 2 inflammation. Notably, eicosanoid levels were independent of oral corticosteroid treatment status but were decreased in subjects on anti-IgE therapy.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research