Asymmetry of Macular Vessel Density in Bilateral Early Open-angle Glaucoma With Unilateral Central 10-2 Visual Field Loss

Conclusions: Significant macular microvascular damage was present in glaucomatous eyes without detectable 10-2 visual field damage. The damage of inferior perifoveal vessel density was more significant in early glaucoma. Macular microvascular damage spatially corresponded with functional and structural damage.
Source: Journal of Glaucoma - Category: Opthalmology Tags: Original Studies Source Type: research

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We would like to clarify some aspects of our article, which appeared in the January 2020 issue of the American Journal of Ophthalmology.1 Although 37 eyes with moderate and advanced glaucoma, 19 eyes with atrophic nonarteritic anterior ischemic optic neuropathy, and 40 eyes of normal subjects were included in this study and imaged using optical coherence tomography angiography (OCT-A), data from 5 glaucoma eyes, the entirety of the data from subjects enrolled from New York Eye and Ear Infirmary, lacked uniform OCT data (retinal nerve fiber layer and ganglion cell complex) as well as adequate quality macular OCT-A data.
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Correspondence Source Type: research
AbstractPurposeTo investigate factors associated with macular vessel density and to analyze their effects according to glaucoma stage.Study designRetrospective cross-sectional study.MethodsA total of 72 healthy eyes and 147 open-angle glaucomatous eyes were studied. All eyes underwent optical coherence tomography and visual field examinations. Clinical variables were compared according to the glaucoma stage. Relationships between macular vessel density (mVD) and other variables were analyzed using linear regression and segmented analyses.ResultsAge (P = 0.010) and signal strength (P
Source: Japanese Journal of Ophthalmology - Category: Opthalmology Source Type: research
Precis: The foveal avascular zone (FAZ) in optical coherence tomography angiography is significantly correlated with retinal inner layer thickness, Humphrey field analyzer (HFA) 10-2 sensitivity threshold, and mean deviation (MD) value in open-angle glaucoma patients. Purpose: The purpose of this study was to measure the FAZ area using optical coherence tomography angiography and investigate its relationship with retinal inner layer thickness and visual field defects in eyes with open-angle glaucoma. Participants and Methods: A total of 52 eyes with open-angle glaucoma from 52 patients. FAZ area was measured using ...
Source: Journal of Glaucoma - Category: Opthalmology Tags: Original Studies Source Type: research
CONCLUSION: NMOSD and POAG have specific patterns of macular structural and vascular changes associated with pathophysiology. Our results indicate that FAZ could be a sensitive biomarker of macular changes in NMOSD. PMID: 32430343 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
Précis: In primary open-angle glaucoma (POAG), unlogged mean macular hemifield visual field sensitivity correlates significantly better with superficial capillary vessel density (VD) than with ganglion cell complex (GCC) thickness of the opposite macular hemifield. Purpose: The aim of this study was to compare the relationship of the spatially corresponding superficial retinal capillary VD and retinal thickness parameters with the corresponding visual field sensitivity, for the superior and inferior macula, and the superotemporal and inferotemporal peripapillary sectors, respectively. Patients and Methods: O...
Source: Journal of Glaucoma - Category: Opthalmology Tags: Original Studies Source Type: research
Conclusion: PD at the central 3 mm around the fovea is comparable between HTG and NTG. Significant correlation with age and MD was shown in both groups. PMID: 32011184 [PubMed - as supplied by publisher]
Source: Current Eye Research - Category: Opthalmology Authors: Tags: Curr Eye Res Source Type: research
Purpose: To investigate the hypothesis that macular structure, function, and vessel density (VD) measurements can predict foveal threshold (FT) outcomes in glaucomatous eyes. Materials and Methods: One hundred ninety-five eyes from 195 subjects (134 subjects with early-to-moderate stage open-angle glaucoma and 61 healthy controls) who underwent optical coherence tomography angiography imaging and 24-2 visual field (VF) testing with FT measurements on the same day were retrospectively enrolled in this study. The association of FT with macular structural/functional/VD measurements was evaluated using partial correlation...
Source: Journal of Glaucoma - Category: Opthalmology Tags: Original Studies Source Type: research
Authors: Zhu X, Zeng W, Wu S, Chen X, Zheng T, Ke M Abstract Purpose: To investigate the changes of retinal nerve fiber layer (RNFL) in patients after an attack of primary acute angle closure glaucoma (PAACG) and to assess the impact of attack time on prognosis of retinal changes. Design: cross-sectional study. Methods: Twenty-six patients with unilateral PAACG attack and cataracts from 2017 to 2019 were enrolled. Eyes with PAACG attack time less than 1 day constituted the group A (n = 13), while eyes with PAACG attack time more than 1 day constituted the group B (n = 13). All pa...
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research
Authors: Pahlitzsch M Abstract The ability to use and control primary neuroprotective agents is a promising approach for future treatment designs in neurodegenerative diseases, particularly in glaucoma. Previous drug and surgical approaches aim to prevent secondary neuroprotection by reducing intraocular pressure. Imaging procedures play a fundamental role in diagnostics and therapy monitoring. The potential importance of DARC technology (= detection of apoptotic retinal cells: visualisation of retinal cells by fluorescence-labeled annexin V = ANX776 using the cSLO technology) in everyday clinical practice l...
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
Abstract Purpose To evaluate macular and radial peripapillary capillary vessel densities (RPC VD) across normal, pre-perimetric (PPG) and early perimetric primary open-angle glaucoma (EG) using optical coherence tomography angiography (OCTA). Materials and Methods Forty-four PPG eyes, 42 EG eyes, and 41 normal eyes were consecutively enrolled. All subjects underwent visual field, OCT and OCTA examinations. Macular vessel densities were measured in superficial layer. RPC VD was measured within a 750-μm-wide elliptical annulus extending outward from disc boundary. Diagnostic ability was evaluated with area under ...
Source: Current Eye Research - Category: Opthalmology Authors: Tags: Curr Eye Res Source Type: research
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