Dissecting the cellular mechanism of prostacyclin analogue iloprost in reversing vascular dysfunction in scleroderma

ConclusionsOur data suggests that the long ‐lasting effects of iloprost reflect its ability to stabilize adherens junctions, resulting in increased tubulogenesis and barrier function, and reduced Endo‐MT. These results provide a mechanistic basis for the use of iloprost in treating SSc patients with RP and DU.

Source: Arthritis and Rheumatology - September 30, 2020 Category: Rheumatology Authors: Pei ‐Suen Tsou, Pamela J. Palisoc, Nicholas A. Flavahan, Dinesh Khanna Tags: FULL LENGTH Source Type: research