Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication

In this study, Klann et  al. dissected the host cell signaling landscape upon infection with SARS-CoV-2. Mapping differential signaling networks identified a number of pathways activated during infection. Drug-target network analysis revealed potential therapeutic targets. Growth factor receptor signaling was highly activ ated upon infection and its inhibition prevented SARS-CoV-2 replication in cells.

Source: Molecular Cell - August 9, 2020 Category: Cytology Authors: Kevin Klann, Denisa Bojkova, Georg Tascher, Sandra Ciesek, Christian M ünch, Jindrich Cinatl Tags: Resource Source Type: research