ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation
Wang et al. demonstrate that ppGpp, the universally conserved growth regulator in bacteria, directly inhibits the purine nucleotide salvage enzyme Gsk. By characterizing a Gsk variant that is insensitive to ppGpp, they demonstrate that inhibiting purine nucleotide synthesis is required during starvation t o maintain levels of the metabolite pRpp, which is required for synthesizing histidine and tryptophan.
Source: Molecular Cell - Category: Cytology Authors: Boyuan Wang, Robert A. Grant, Michael T. Laub Tags: Article Source Type: research