Early mechanical ventilation in patients with Guillain-Barr é syndrome at high risk of respiratory failure: a randomized trial

About 30% of patients with Guillain-Barr é syndrome become ventilator dependent, of whom roughly 75% develop pneumonia. This trial aimed at assessing the impact of early mechanical ventilation (EMV) on pneumoni...
Source: Annals of Intensive Care - Category: Intensive Care Authors: Tags: Research Source Type: research

Related Links:

We describe a rare case of post-infective Acute Motor Axonal Neuropathy (AMAN) variant of Guillain-Barr è Syndrome (GBS) associated with myelitis and anti-GD1b positivity after SARS-CoV-2 infection. The patient referred to the hospital reporting a history of ten days lasting moderate fever, myalgia and anosmia, with the onset of progressive quadriparesis and ascending paraesthesias in the four limbs since five days from defervescence. A chest computed tomography demonstrated interstitial pneumonia with “ground glass opacities”, suggesting Coronavirus disease (COVID-19). The patient exhibited three negati...
Source: Journal of Neurology - Category: Neurology Source Type: research
AbstractRespiratory viruses are opportunistic pathogens that infect the upper respiratory tract in humans and cause severe illnesses, especially in vulnerable populations. Some viruses have neuroinvasive properties and activate the immune response in the brain. These immune events may be neuroprotective or they may cause long-term damage similar to what is seen in some neurodegenerative diseases. The new “Severe Acute Respiratory Syndrome Coronavirus 2” (SARS-CoV-2) is one of the Respiratory viruses causing highly acute lethal pneumonia coronavirus disease 2019 (COVID-19) with clinical similarities to those rep...
Source: Neurological Sciences - Category: Neurology Source Type: research
Authors: Wada S, Nagasaki Y, Arimizu Y, Shimo M, Matsukuma Y, Okamoto M, Yoshida S, Ohashi I, Hashimoto G, Kuwashiro T, Yasaka M, Okada Y Abstract A 69-year-old man was admitted to our hospital under diagnosis of pneumonia due to SARS-CoV-2 (Day 0). He underwent endotracheal intubation from Day 3. Although his respiratory condition improved and anesthetic drugs were discontinued, no cough reflex was observed despite intubation having been performed until Day 17. His tendon reflexes were also diminished. We suspected that he had developed Guillain-Barré syndrome (GBS), and administered intravenous immunoglobu...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
AbstractIn December 2019, a cluster of cases with 2019 Novel Coronavirus pneumonia from Wuhan, China, aroused worldwide concern due to an escalating outbreak in all the countries in the world. Coronavirus belongs to a family of single-stranded RNA viruses, which includes severe acute respiratory syndrome (SARS-CoV) and Middle East respiratory syndrome (MERS-CoV), that have caused human epidemics with high fatality. The spectrum of the novel coronavirus disease (SARS-Co-2 or COVID-19) ranges from asymptomatic infections to fatal pneumonia, and differs from other viral pulmonary infections. MERS-CoV is known to be potentiall...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
At the end of 2019, a novel pneumonia syndrome was identified in Wuhan, a city in the Hubei Province of China [1]. In February 2020, the World Health Organization designated the disease Covid-19, which stands for coronavirus disease 2019 [2]. While the majority of patients have mild symptoms without pneumonia or mild pneumonia, the clinical spectrum of symptomatic Covid-19 cases ranges from mild to critically ill [3]. As previously reported, patients with Covid-19 may show a range of immune complications, such as autoimmune hemolytic anemia (OIHA), immune thrombocytopenia (ITP), Guillain-Barr é and antiphospholipid ...
Source: Thrombosis Research - Category: Hematology Authors: Tags: Letter to the Editors-in-Chief Source Type: research
ConclusionsNeurological manifestations of COVID-19 are not rare, especially large vessel stroke, Guillain –Barre syndrome, and meningoencephalitis. Moving forward, further studies are needed to clarify the prevalence of the neurological complications of SARS-CoV-2 infection, investigate their biological backgrounds, and test treatment options. Physicians should be cautious not to overlook other neurol ogical diagnoses that can mimic COVID-19 during the pandemic.
Source: Journal of Neurology - Category: Neurology Source Type: research
At the time of this writing, healthcare systems are facing worldwide the pandemic of the coronavirus severe acute respiratory coronavirus 2 (SARS-COV-2) and its associated disease, named cronavirus disease 19 (COVID-19). This virus is a new human pathogen, and currently, there are no specific treatment options.1 COVID-19 mostly affects the respiratory system, ranging from mild flu-like symptoms to severe pneumonia, but extrarespiratory multisystemic involvement has also been reported.2 Li et al.3 recently described the neuroinvasive potential of COVID-19, but, to our knowledge, no case of acute dysimmune neuropathy has bee...
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Autoimmune diseases, Peripheral neuropathy, Guillain-Barre syndrome, COVID-19 Clinical/Scientific Notes Source Type: research
ConclusionsEarly tracheostomy was not significantly associated with decreased mortality or morbidity in patients with GBS requiring MV for more than 1  week.
Source: Neurocritical Care - Category: Neurology Source Type: research
AbstractMany neurological diseases may cause acute respiratory failure (ARF) due to involvement of bulbar respiratory center, spinal cord, motoneurons, peripheral nerves, neuromuscular junction, or skeletal muscles. In this context, respiratory emergencies are often a challenge at home, in a neurology ward, or even in an intensive care unit, influencing morbidity and mortality. More commonly, patients develop primarily ventilatory impairment causing hypercapnia. Moreover, inadequate bulbar and expiratory muscle function may cause retained secretions, frequently complicated by pneumonia, atelectasis, and, ultimately, hypoxe...
Source: Neurological Sciences - Category: Neurology Source Type: research
Conclusion: Mechanically ventilated GBS patients have higher disease severity at admission along with more in-hospital complications, length of stay, and disability compared with MG patients. Potential explanations for these findings include delay in the diagnosis, poor response to immunotherapy particularly in patients with axonal GBS variant, or longer recovery time after nerve damage. PMID: 31311172 [PubMed - in process]
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
More News: Guillain-Barr Syndrome | Intensive Care | Men | Pneumonia | Respiratory Medicine