Muscle function & homeostasis / molecular therapeutic approaches

Skeletal muscle atrophy is a major consequence of several pathophysiological conditions, including neuromuscular diseases, disuse (limb immobilization, space flight), aging (sarcopenia) and other wasting conditions (i.e. cancer cachexia). Basically, a disequilibrium between anabolic/catabolic pathways leads to progressive loss of muscle mass and functional impairment. The aim of translational research in this field is to identify anabolic compounds able to support protein synthesis and muscle mass, restoring muscle function and metabolism.

Source: Neuromuscular Disorders - September 28, 2020 Category: Neurology Authors: P. Mantuano, F. Sanarica, O. Cappellari, B. Boccanegra, N. Tarantino, E. Conte, M. De Bellis, G. Camerino, S. Pierno, A. De Luca Source Type: research