Target identification of a macrocyclic hexaoxazole G-quadruplex ligand using a post-target-binding visualization

Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/D0CC04957C, CommunicationMizuho Yasuda, Yue Ma, Sachiko Okabe, Yuki Wakabayashi, Dongdong Su, Young-Tae Chang, Hiroyuki Seimiya, Masayuki Tera, Kazuo Nagasawa Macrocyclic hexaoxazoles (6OTDs) are G-quadruplex (G4) ligands, and some derivatives, such as L2H2-6OTD (1a) bearing two aminobutyl side chains, show cytotoxicity towards cancer cells. To identify the cellular target of... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research