Prognostic significance of spread through air spaces in pulmonary metastases from colorectal cancer

Surgical resection for pulmonary metastases from colorectal cancer (PM-CRC) has been found to be associated with prolonged relapse-free survival, and it has been considered a practical standard therapy [1,2]. According to a systematic review of patients undergoing pulmonary metastasectomy for CRC, the median 5-year overall survival (OS) was 52.5 % [3]. Along with the development of molecular targeted therapy, 5-year OS has improved to more than 70 % in the last decade [4]. Completeness of resection is a known predictor of survival, as well as size and number of PM, intrathoracic lymph node involvement, pre-metastasectomy serum carcinoembryonic antigen (CEA) level, and disease-free interval [3,5 –11].
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research