Oral amyloidosis as primary manifestation of multiple myeloma in elderly women

Multiple myeloma (MM) is an uncommon plasma cell malignancy with a slight male predilection. Up to 15% of patients with MM present an abnormal deposition of amyloid tissue. In the oral cavity, this deposition develops as macroglossia. A 69-year-old woman presented with a 9-month history of painless tongue enlargement. Microscopic analysis showed amorphous and eosinophilic deposits in the dermis compatible with amyloid. Congo red stain was positive. Myelogram verified 29% of plasma cells, and monoclonal isolated lambda protein was found in the urine and serum.

Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - August 31, 2020 Category: ENT & OMF Authors: DAPHINE CAXIAS TRAVASSOS, MAYARA SANTOS DE CASTRO, GIOVANNA LOPES CARVALHO, JOS É ERIVALDO DA SILVA MENDES, CLÓVIS ANTÔNIO LOPES PINTO, JAQUELINE SAPELLI, MATHEUS HENRIQUE ALVES DE LIMA Tags: 20190522 Source Type: research