MicroRNAs and Long Noncoding RNAs in Coronary Artery Disease

Noncoding RNAs (ncRNAs), including long noncoding RNAs and microRNAs, play an important role in coronary artery disease onset and progression. The ability of ncRNAs to simultaneously regulate many target genes allows them to modulate various key processes involved in atherosclerosis, including lipid metabolism, smooth muscle cell proliferation, autophagy, and foam cell formation. This review focuses on the therapeutic potential of the most important ncRNAs in coronary artery disease. Moreover, various other promising microRNAs and long noncoding RNAs that attract substantial scientific interest as potential therapeutic targets in coronary artery disease and merit further investigation are presented.

Source: Cardiology Clinics - September 16, 2020 Category: Cardiology Authors: Lukasz Zareba, Alex Fitas, Marta Wolska, Eva Junger, Ceren Eyileten, Zofia Wicik, Salvatore De Rosa, Jolanta M. Siller-Matula, Marek Postula Source Type: research