Induction and transmission of oncogene-induced senescence.

Induction and transmission of oncogene-induced senescence.
Cell Mol Life Sci. 2020 Sep 16;:
Authors: Rattanavirotkul N, Kirschner K, Chandra T
Abstract
Senescence is a cellular stress response triggered by diverse stressors, including oncogene activation, where it serves as a bona-fide tumour suppressor mechanism. Senescence can be transmitted to neighbouring cells, known as paracrine secondary senescence. Secondary senescence was initially described as a paracrine mechanism, but recent evidence suggests a more complex scenario involving juxtacrine communication between cells. In addition, single-cell studies described differences between primary and secondary senescent end-points, which have thus far not been considered functionally distinct. Here we discuss emerging concepts in senescence transmission and heterogeneity in primary and secondary senescence on a cellular and organ level.
PMID: 32936311 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - September 15, 2020 Category: Cytology Authors: Rattanavirotkul N, Kirschner K, Chandra T Tags: Cell Mol Life Sci Source Type: research