Castanospermine reduces Zika virus infection-associated seizure by inhibiting both the viral load and inflammation in mouse models
Publication date: Available online 16 September 2020Source: Antiviral ResearchAuthor(s): Anil M. Tharappel, Yichen Cheng, Eric H. Holmes, Gary K. Ostrander, Hengli Tang
Publication date: Available online 9 August 2020Source: Antiviral ResearchAuthor(s): Nitin Sharma, Oliver Prosser, Prateek Kumar, Andrew Tuplin, Rajanish Giri
Abstract The recurrent public health threat imposed by Zika Virus (ZIKV) in various geographical areas necessitates the immediate development of antiviral compounds or vaccines. Flaviviral Envelope (E) proteins are essential for host-cell recognition and virion entry. Consequently, they represent an important target for antiviral therapy, with the aim of preventing viral spread during early stages of infection. Due to conformational rearrangement during entry, flavivirus E proteins present several alternative conformations as potential antiviral targets - for blocking entry or virus-host membrane fusion. We previo...
Publication date: August 2020Source: Antiviral Research, Volume 180Author(s): Juliana Lemos Del Sarto, Rebeca de Paiva Froes Rocha, Leda Bassit, Isabella Guimarães Olmo, Bruno Valiate, Celso M. Queiroz-Junior, Carolina da Silva Gouveia Pedrosa, Fabíola Mara Ribeiro, Marilia Zaluar Guimarães, Stevens Rehen, Franck Amblard, Longhu Zhou, Bryan D. Cox, Christina Gavegnano, Vivian Vasconcelos Costa, Raymond F. Schinazi, Mauro Martins Teixeira
Publication date: Available online 7 July 2020Source: Antiviral ResearchAuthor(s): Noemi R. Gardinali, Renato S. Marchevsky, Jaqueline M. Oliveira, Marcelo Pelajo-Machado, Tatiana Kugelmeier, Marcio P. Castro, Aline C.A. Silva, Douglas P. Pinto, Lais B. Fonseca, Leandro S. Vilhena, Heliana M. Pereira, Sheila M.B. Lima, Emily H. Miranda, Gisela F. Trindade, José H.R. Linhares, Stephanie A. Silva, Juliana Gil Melgaco, Ada M.B. Alves, Julio Moran, Maria C.C. Silva
Publication date: Available online 20 June 2020Source: Antiviral ResearchAuthor(s): Juliana Lemos Del Sarto, Rebeca de Paiva Froes Rocha, Leda Bassit, Isabella Guimarães Olmo, Bruno Valiate, Celso M. Queiroz-Junior, Carolina da Silva Gouveia Pedrosa, Fabíola Mara Ribeiro, Marilia Zaluar Guimaraes, Stevens Rehen, Franck Amblard, Longhu Zhou, Bryan D. Cox, Christina Gavegnano, Vivian Vasconcelos Costa, Raymond F. Schinazi, Mauro Martins Teixeira
The COVID-19 pandemic has had significant global consequences, with healthcare systems stretched to their limits, a growing death toll, and economic devastation as economies came grinding to a halt. The pandemic and its aftereffects will be with u...
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Publication date: Available online 29 April 2020Source: Antiviral ResearchAuthor(s): Rafaela Batista Molás, Milene Rocha Ribeiro, Maria Juliana C Ramalho dos Santos, Alexandre Urban Borbely, Denise Vaz Oliani, Antonio Hélio Oliani, Suchita Nadkarni, Maurício Lacerda Nogueira, Jusciele Brogin Moreli, Sonia Maria Oliani
In conclusion, anisomycin is a potent and selective in vitro inhibitor of DENV and ZIKV that impairs a post-entry step of viral replication; and a low-dose anisomycin treatment may provide some minimal benefit in a mouse model.
Publication date: Available online 31 January 2020Source: Antiviral ResearchAuthor(s): Wioletta Rut, Katarzyna Groborz, Linlin Zhang, Sylwia Modrzycka, Marcin Poreba, Rolf Hilgenfeld, Marcin DragAbstractWest Nile virus (WNV) and Dengue virus (DENV) are mosquito-borne pathogenic flaviviruses. The NS2B-NS3 proteases found in these viruses are responsible for polyprotein processing and are therefore considered promising medical targets. Another ortholog of these proteases is found in Zika virus (ZIKV). In this work, we applied a combinatorial chemistry approach – Hybrid Combinatorial Substrate Library (HyCoSuL), to comp...