Graphene oxide inhibits cell migration and invasion by destroying actin cytoskeleton in cervical cancer cells.

CONCLUSION: GO exhibited inhibitory effects on cell migration and invasion possibly by destroying actin cytoskeleton in Hela cells, which is a potential component of the Smad and JNK signalling pathways.
METHODS: GO was prepared and chracterized by UV visible light absorption spectroscopy and atomic force microscopy. Hela cells were treated with Go at different dose levels. Then, in vitro cytotoxicity of GO was evaluated by the MTT assay, colony-forming assay and cell apoptosis assay. The inhibitory effects of GO on tumor cell migration and invasion as well as actin cytoskeleton were explored using Hela cells.
PMID: 32924971 [PubMed - as supplied by publisher]

Source: Aging - September 13, 2020 Category: Biomedical Science Authors: Wang J, Wang P, He Y, Liu X, Wang S, Ma C, Tian X, Wang J, Wu X Tags: Aging (Albany NY) Source Type: research