HMGA2 involvement in uterine leiomyomas development through angiogenesis activation

Uterine leiomyoma (UL) is the most common benign estrogen-dependent tumor in women of reproductive age, affecting 25% of women and has a cumulative incidence of 70% in women by the age of 50 years because leiomyomas can be present without symptoms in most of them (1). However, 15% to 30% of women with UL present symptoms such as metrorrhagia, pelvic pain or pressure, and urinary incontinence, as well as infertility, miscarriage, and preterm birth. Leiomyomas arise from overgrowth of extracellular matrix and smooth muscle derived from myometrium, which contribute to tumor expansion (1).
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research