Statins Going Generic Saved Medicare Billions

Statins are the most popular type of cholesterol-lowering drug in the United States, prescribed to more than 35 million people.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Authors: Abdel-Sattar AR, Abo-Saif AA, Aboyoussef AM Abstract The present study aimed to evaluate the possible hepatoprotective effects of nicorandil and atorvastatin against experimentally induced liver fibrosis.Wistar male rats wereassigned tofivegroups;control group, fibrosis group, the remaining three groups received in addition to CCl4, N-acetyl cysteine (300 mg/kg), nicorandil(15 mg/kg) and atorvastatin (20 mg/kg), respectively.Liver fibrosis was induced by intraperitoneal injection of rats with CCl4(2ml/kg), twice weekly for five consecutive weeks.All treatments were administereddaily st...
Source: Immunopharmacology and Immunotoxicology - Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research
This study investigates miRNA expression profiles from peripheral blood specimens in patients with hypercholesterolemia. Our findings demonstrated that miRNA regulations could be involved in statin-induced inflammation modulation in immune cells, thereby providing an anti-inflammatory approach to reduce residual ASCVD risk in individuals with optimal lipid control.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens synthetic construct Source Type: research
AbstractPurpose of ReviewMucormycosis is an aggressive disease with high (>  30–50%) mortality. Many attempts have been made to improve the outcome including global consensus guideline to manage mucormycosis. In this review, we discuss various aspects of the current management strategies of mucormycosis.Recent FindingsNew global consensus guideline not only addressed the management issues in developed countries but also recommended algorithm in a resource-limiting environment. Isavuconazole, a new water-soluble triazole with good pharmacokinetics and safety profile, has emerged as a promising agent with ant...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
PMID: 32985673 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
“Best medical treatment” are the bywords in the management of peripheral arterial disease (PAD), with lipid lowering therapy (LLT) prescribed de rigueur for arteriopaths. Typical LLT options comprise statins (more accurately, “vastatins”), which are effective in reducing all lipid profile fr actions, including triglycerides (TGs) and low density lipoprotein-cholesterol (LDL-C), where attention is focused.1,2 Statins represent a change from prior yet complementary LLT such as fibrates,3 and gut absorption inhibitors like ezetimibe.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Tags: Editorial Source Type: research
Cardiovascular disease is a leading cause of morbidity and mortality in the United States. Since their initial discovery, statins have become the first-line treatment for decreasing the risk of cardiovascular disease. Although they are typically well tolerated, side effects do occur and tend to affect the musculature. Most side effects are benign and resolve after discontinuing the statin. A subset of immune-mediated necrotizing myositis, anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) myopathy is a rare disease that occurs in 0.9 to 1.4 cases per 100,000 people. It causes significant muscle weakness that does...
Source: Journal of the American Board of Family Medicine - Category: Primary Care Authors: Tags: Brief Reports Source Type: research
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results. Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
PMID: 32981081 [PubMed - as supplied by publisher]
Source: The Australasian Journal of Dermatology - Category: Dermatology Authors: Tags: Australas J Dermatol Source Type: research
Conclusions: 17β-Estradiol exhibits the greatest efficacy on the attenuation of obesity with the least harmful effect on skeletal muscle in a model of menopause with obesity, yet its effect on the treatment of hyperlipidemia is inferior to those of standard lipid-lowering agents.
Source: Menopause - Category: OBGYN Tags: Original Studies Source Type: research
No abstract available
Source: Menopause - Category: OBGYN Tags: Letters to the Editor Source Type: research
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