Severe Mycoplasma pneumoniae pneumonia requiring intensive care in children, 2010–2019

Publication date: Available online 15 September 2020Source: Journal of the Formosan Medical AssociationAuthor(s): Kuan-Lin Lee, Chieh-Ming Lee, Te-Liang Yang, Ting-Yu Yen, Luan-Yin Chang, Jong-Min Chen, Ping-Ing Lee, Li-Min Huang, Chun-Yi Lu
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research

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AbstractThe novel coronavirus outbreak induces many concerns about the management of pregnancy, as well as rheumatic and musculoskeletal diseases. The very rapid spread of the infection throughout all inhabited continents leads to a fast-growing number of infected with SARS-CoV-2 and requires answers and special recommendations to the most vulnerable group of people: pregnant woman and patients on immunomodulatory or immunosuppressive treatment. A systematic literature search was performed in Embase, MEDLINE, and Scopus database for studies describing COVID-19 infection in pregnant women diagnosed with rheumatic and muscul...
Source: Rheumatology International - Category: Rheumatology Source Type: research
Publication date: Available online 25 September 2020Source: Journal of Critical CareAuthor(s): Yasser Sakr, Manuela Giovini, Marc Leone, Giacinto Pizzilli, Andreas Kortgen, Michael Bauer, Tommaso Tonetti, Gary Duclos, Laurent Zieleskiewicz, Samuel Buschbeck, V. Marco Ranieri, Elio Antonucci
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that administration of metronidazole (15 mg/kg, PO, q 8 h) or imipenem (10 mg/kg, IV, q 8 h) resulted in their accumulation in the pleural fluid in healthy horses and concentrations were likely to be effective for the treatment of pneumonia and pleuropneumonia caused by Bacteroides spp. PMID: 32969731 [PubMed - in process]
Source: American Journal of Veterinary Research - Category: Veterinary Research Authors: Tags: Am J Vet Res Source Type: research
In this study, a state-of-the-art custom U-Net model is presented with a dice similarity coefficient performance of 99.6% along with a transfer learning VGG-19 based model for COVID-19 versus pneumonia differentiation exhibiting an area under curve of 96.1%. The above was significantly improved over the baseline model trained with no segmentation in selected tomographic slices of the same dataset. The presented study highlights the importance of a robust preprocessing protocol for image analysis within a heterogeneous imaging dataset and assesses the potential diagnostic value of the presented COVID-19 model by comparing i...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
"Such issues get resolved in about six weeks in most cases. We advise them to exercise, have a diet with green leafy vegetables and multivitamins. But there is a small percentage who have serious damage. We have seen post-Covid fibrosis, wherein if you have pneumonia in your lungs, it leads to scarring of the lungs and the lungs do not recover."
Source: The Economic Times - Category: Consumer Health News Source Type: news
Publication date: Available online 24 September 2020Source: Respiratory Medicine Case ReportsAuthor(s): Tsuyoshi Shirai, Takahiro Mitsumura, Kei Aoyagi, Tsukasa Okamoto, Moe Kimura, Taku Gemma, Takaaki Shigematsu, Junichi Takahashi, Seishin Azuma, Riku Yoshizuka, Hirokazu Sasaki, Nao Urushibata, Kanae Ochiai, Kenichi Hondo, Koji Morishita, Junichi Aiboshi, Yasuhiro Otomo, Yasunari Miyazaki
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Background: The Japan Society for Respiratory Endoscopy performed a nationwide survey to evaluate the current status and complications of bronchoscopy. Data on deaths due to bronchoscopy, complications after bronchoscopy, and particularly, complications of forceps biopsy were surveyed. Methods: The survey form was mailed to 532 facilities accredited by the society. The numbers of procedures, complications, and deaths were investigated. Results: The response rate was 79.1% (421 facilities). Deaths attributable to diagnostic bronchoscopy occurred in 11 (0.011%) of 98,497 cases. In regards to forceps biopsy, the guid...
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research
Conditions:   Covid19;   Pneumonia Interventions:   Drug: NuSepin® 0.1 mg;   Drug: NuSepin® 0.2 mg;   Drug: Placebo Sponsor:   Shaperon Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract: An 83-year-old man, presenting decreased renal function (estimated glomerular filtration rate 21 mL/min/1.73 m2), was treated for a bone and joint infection (on a trans-metatarsal right foot amputation) caused by Klebsiella Pneumonia sensitive to cefepime. The starting dose (1 g bid) was based on recommendations for patients presenting severe infections. One week after treatment initiation, the patient developed neurotoxicity, exhibiting extremely high plasma cefepime concentrations. Based on TDM, the dose was reduced by 8 times the original dose. This case report highlights the importance of therapeutic drug m...
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Case Report Source Type: research
Background: Cefotiam, a second-generation cephalosporin, is a broad-spectrum antibiotic with good antibacterial action against both gram-negative and gram-positive bacteria. It is used widely in clinical practice, although bacterial drug resistance makes its clinical use problematic. The authors hypothesized that subtherapeutic concentrations of cefotiam leads to bacterial resistance. The present study was conducted to evaluate whether the standard cefotiam dosing regimen resulted in a subtherapeutic concentrations in children. Method: Data were prospectively collected from pediatric patients with suspected or confirm...
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research
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