IFN γ and TNFα synergistically promote galectin 9 secretion by human osteosarcoma cells MG-63 to prevent T cell killing.
CONCLUSION: We found that Galectin-9 is induced by IFNγ and TNFα stimuli in osteosarcoma cells. Furthermore, Tim-3/Galectin-9 pathway contributes to the inducible immunomodulatory functions of osteosarcoma cells, which may provide a new clue to novel strategies for the osteosarcoma therapy.
PMID: 32922595 [PubMed]
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Liu Y, Luo J, Li Y, Cao J, Wang X Tags: Int J Clin Exp Pathol Source Type: research