Syk Inhibitor Attenuates Polymicrobial Sepsis in FcgRIIb-Deficient Lupus Mouse Model, the Impact of Lupus Characteristics in Sepsis

In conclusion, it was easier to induce Syk expression in FcgRIIb−/− macrophages than in WT macrophages. This might be because of the loss of inhibitory signaling, which might be responsible for prominent Syk abundance in the spleens of 40-week-old FcgRIIb−/− mice and the potent effect of Syk inhibitor in lupus mice compared with WT.J Innate Immun
Source: Journal of Innate Immunity - Category: Allergy & Immunology Source Type: research