MicroRNA ‐200b is a potential biomarker of the expression of PD‐L1 in patients with lung cancer

ConclusionsmiR200b can regulate PD ‐L1 expression in lung cancer cells, and miR200b expression in clinical specimens negatively correlated with PD‐L1 expression. Thus, miR200b may be a useful surrogate biomarker for PD‐L1 expression in lung cancer patients.Key pointsSignificant findings of the study
High PD ‐L1 expression was linked to low miR200b expression, whereas low PD‐L1 expression was linked to high miR200b expression in human lung cancer patients. Thus, miR200b overexpression or silencing can control PD‐L1 expression in cancer cells.What this study adds
We demonstrated the potential of miR200b as a surrogate biomarker for PD ‐L1 expression in lung cancer patients.

Source: Thoracic Cancer - September 6, 2020 Category: Cancer & Oncology Authors: Seigo Katakura, Nobuaki Kobayashi, Hisashi Hashimoto, Chisato Kamimaki, Katsushi Tanaka, Sousuke Kubo, Kentaro Nakashima, Shuhei Teranishi, Saki Manabe, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Masaki Yamamoto, Makoto Kudo, Hongmei Piao, Tags: ORIGINAL ARTICLE Source Type: research