Undescribed benzophenone and xanthones from cave-derived Streptomyces sp. CB09001.

Undescribed benzophenone and xanthones from cave-derived Streptomyces sp. CB09001.
Nat Prod Res. 2020 Sep 01;:1-9
Authors: Jiang L, Xiang J, Zhu S, Tang D, Gong B, Pu H, Duan Y, Huang Y
Abstract
A new benzophenone huanglongmycin (HLM) D (1) and two new monomeric xanthones huanglongmycin E (2) and F (3), together with four known aromatic polyketides aloesaponarin II (4) and the previously isolated huanglongmycin A-C (5-7) were obtained from cave-derived Streptomyces sp. CB09001. The structures of 1-3 were established based on 1D, 2D NMR and HRMS data. Compounds 1-7 may be biosynthesized by a type II huanglongmycin polyketide synthase based on gene inactivation of hlmG encoding KSɑ in hlm gene cluster and their plausible biosynthetic mechanism was proposed.
PMID: 32873080 [PubMed - as supplied by publisher]

Source: Natural Product Research - August 31, 2020 Category: Biochemistry Authors: Jiang L, Xiang J, Zhu S, Tang D, Gong B, Pu H, Duan Y, Huang Y Tags: Nat Prod Res Source Type: research