Chemical constituent from the roots of Solanum melongena L. and their potential anti-inflammatory activity.

Chemical constituent from the roots of Solanum melongena L. and their potential anti-inflammatory activity.
Nat Prod Res. 2020 Sep 02;:1-8
Authors: Liu Y, Yin X, Sun YP, Liu Y, Zhou YY, Pan J, Guan W, Yang BY, Kuang HX
Abstract
Three new compounds (1-3), were isolated from the ethanol extract of the roots of Solanum melongena L., together with twenty-seven knowns (4-30). On basis of their 1 D and 2 D NMR data, the chemical structures of islated compounds were elucidated combined with HR-MS and the relative values in literatures. In addition, the isolations were evaluated for the potential anti-inflammatory activity, by virtue of RAW 264.7 cells model induced by lipopolysaccharide (LPS)in vitro inhibitory activities on nitric oxide (NO) production. Compounds 12 and 21 showed moderate inhibition of NO production with IC50 values of 32.8 and 20.2 μM, respectively.
PMID: 32878487 [PubMed - as supplied by publisher]

Source: Natural Product Research - September 1, 2020 Category: Biochemistry Authors: Liu Y, Yin X, Sun YP, Liu Y, Zhou YY, Pan J, Guan W, Yang BY, Kuang HX Tags: Nat Prod Res Source Type: research