Bortezomib and cyclophosphamide based chemo-mobilization in multiple myeloma.

Bortezomib and cyclophosphamide based chemo-mobilization in multiple myeloma. Int J Hematol. 2020 Sep 02;: Authors: Bagal B, Gokarn A, Punatar S, Das S, Bonda A, Nayak L, Chichra A, Kannan S, Mathew LJ, Tembhare P, Patkar N, Poojary M, Ojha S, Subramanian PG, Gujral S, Khattry N Abstract Hematopoietic stem and progenitor cell (HSPC) mobilization regimens in multiple myeloma typically use filgrastim (GCSF) alone or combination of GCSF with plerixafor or high-dose cyclophosphamide. Murine model and human studies have shown HSPC mobilization potential of bortezomib. A total of 37 patients underwent mobilization using bortezomib 1.3 mg/m2 on day 1, 4, 8 and 11, cyclophosphamide 1 g/m2 on day 8 and 9, and GCSF 10 μg/kg from day 10 (B-Cy-GCSF). This regimen was compared with our earlier cohort of patients where cyclophosphamide was given at dose of 1 g/m2 on day 1 and day 2 followed by GCSF 10 μg/kg from day 4 (Cy-GCSF). In B-Cy-GCSF group, median CD34 cells collected were 9.21 × 106/kg (range 4.95-17.1) while in the Cy-GCSF cohort, the median CD34 cell yield was 8.2 × 106/kg (0.4-24.2). Target CD34 cells yield of 5 × 106/kg was achieved with single apheresis in 58.6% of patients after B-Cy-GCSF mobilization as compared to 44.3% in Cy-GCSF group (p = 0.07). Three patients failed mobilization after Cy-GCSF, while no patients failed mobilization in bortezomib group. Addition of bortezomib to Cy-GCSF mobilization sh...
Source: International Journal of Hematology - Category: Hematology Authors: Tags: Int J Hematol Source Type: research