Effects of Macitentan and Its Active Metabolite on Cultured Human Systemic Sclerosis and Control Skin Fibroblasts.

CONCLUSION: Macitentan and ACT-132577 seem to downregulate in vitro the profibrotic myofibroblast phenotype induced by ET-1 in cultured human SSc skin fibroblasts.
PMID: 25593238 [PubMed - as supplied by publisher]

Source: J Rheumatol - January 15, 2015 Category: Rheumatology Authors: Cutolo M, Montagna P, Brizzolara R, Smith V, Alessandri E, Villaggio B, Sulli A, Tavilla PP, Pizzorni C, Soldano S Tags: J Rheumatol Source Type: research