The triglyceride/glucose ratio is a reliable index of fasting insulin resistance: Observations from hyperinsulinemic-euglycaemic clamp studies in young, normoglycaemic males from southern India

Publication date: Available online 29 August 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Shajith Anoop, Felix K. Jebasingh, Grace Rebekah, Mathews Edatharayil Kurian, Venkataraghava R. Mohan, Geethanjali Finney, Nihal Thomas
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research

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MAGMA. 2021 Aug 2. doi: 10.1007/s10334-021-00946-9. Online ahead of print.ABSTRACTBACKGROUND: There is increasing appreciation of the association of obesity beyond co-morbidities, such as cancers, Type 2 diabetes, hypertension, and stroke to also impact upon the muscle to give rise to sarcopenic obesity. Phenotypic knowledge of obesity is crucial for profiling and management of obesity, as different fat-subcutaneous adipose tissue depots (SAT) and visceral adipose tissue depots (VAT) have various degrees of influence on metabolic syndrome and morbidities. Manual segmentation is time consuming and laborious. Study focuses o...
Source: Magma - Category: Radiology Authors: Source Type: research
We present a broad overview of novel insights linking cardiovascular derangements and CKD with a focus on metabolic disorders affecting PRAT. We also argue that the confluence among these pathways may open several perspectives for future pharmacological therapies against CKD and CVD possibly by modulating PRAT immunometabolism.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Clin Exp Pharmacol Physiol. 2021 Aug 1. doi: 10.1111/1440-1681.13561. Online ahead of print.ABSTRACTType-2 diabetes mellitus is a chronic and progressive disease that requires long-term management. Thus, Dipeptidyl peptidase-4 inhibitors (DPP-4) need more investigations about their efficacy and safety profile as there is still no evidence of whether DPP-4 inhibitors can be used as 1st line option for type2 diabetes drug naïve patients. In this randomized case-controlled study, 60 drug-naïve type 2 diabetic subjects were randomized into 3 groups, each group comprising 20 subjects. Group 1 was given sitagliptin 100...
Source: Clinical and Experimental Pharmacology and Physiology - Category: Drugs & Pharmacology Authors: Source Type: research
Orv Hetil. 2021 Aug 1;162(31):1244-1251. doi: 10.1556/650.2021.32125.ABSTRACTÖsszefoglaló. Bevezetés: A metabolikus szindróma előfordulása és jelentősége az elhízás prevalenciájával arányosan megnövekedett. Diagnosztizálása különböző kritériumrendszerek segítségével történhet. Célkitűzés: A kutatás célkitűzése volt egy hátrányos helyzetű település lakosságánál a metabolikus szindr&oa...
Source: Orvosi Hetilap - Category: General Medicine Authors: Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
CONCLUSION: MetS, a potentially modifiable risk factor, is associated with radiographic DIP and PIP OA and longitudinal hand pain incidence while sparing MCPs and CMC1s. Nodal and erosive HOA phenotypes are associated with MetS, suggestive of possible distinct pathophysiology.PMID:34329188 | DOI:10.3899/jrheum.210189
Source: Journal of Rheumatology - Category: Rheumatology Authors: Source Type: research
CONCLUSION: MetS, a potentially modifiable risk factor, is associated with radiographic DIP and PIP OA and longitudinal hand pain incidence while sparing MCPs and CMC1. Nodal and erosive OA phenotypes are associated with MetS, suggestive of possible distinct pathophysiology.PMID:34329188 | DOI:10.3899/jrheum.210189
Source: J Rheumatol - Category: Rheumatology Authors: Source Type: research
J Obes. 2021 Jul 16;2021:6613385. doi: 10.1155/2021/6613385. eCollection 2021.ABSTRACTObesity is a global health problem with a broad set of comorbidities, such as malnutrition, metabolic syndrome, diabetes, systemic hypertension, heart failure, and kidney failure. This review describes recent findings of neuroimaging and two studies of cell density regarding the roles of overnutrition-induced hypothalamic inflammation in neurodegeneration. These studies provided consistent evidence of smaller cortical thickness or reduction in the gray matter volume in people with overweight and obesity; however, the investigated brain re...
Source: Journal of Obesity - Category: Eating Disorders & Weight Management Authors: Source Type: research
CONCLUSION: MetS, a potentially modifiable risk factor, is associated with radiographic DIP and PIP OA and longitudinal hand pain incidence while sparing MCPs and CMC1. Nodal and erosive OA phenotypes are associated with MetS, suggestive of possible distinct pathophysiology.PMID:34329188 | DOI:10.3899/jrheum.210189
Source: J Rheumatol - Category: Rheumatology Authors: Source Type: research
Am J Clin Nutr. 2021 Jul 28:nqab250. doi: 10.1093/ajcn/nqab250. Online ahead of print.ABSTRACTBACKGROUND: Uncertainty remains about the estimates of the effects for resveratrol supplementation, including the certainty of the evidence for each estimate and the magnitude of the observed impact based on the minimal important difference.OBJECTIVE: We aimed to provide an overview of the effects of resveratrol supplementation, in comparison to control groups, for the management of cardiometabolic risk factors in patients with type 2 diabetes (T2D), metabolic syndrome (MetS), and nonalcoholic fatty liver disease (NAFLD).METHODS: ...
Source: Am J Clin Nutr - Category: Nutrition Authors: Source Type: research
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