Vitamin D supplementation: upper limit for safety revisited?

Vitamin D supplementation: upper limit for safety revisited? Aging Clin Exp Res. 2020 Aug 28;: Authors: Rizzoli R Abstract Vitamin D overdosing includes hypercalcemia, hypercalciuria, and mineral deposits in soft tissues. A safety upper limit of 4000 IU/day, which is consistently accepted, has been challenged, since the risk of adverse events in other systems than calcium-phosphate homeostasis may depend not only on the dose, but on the outcome, the treatment regimen, and possibly the age, sex and vitamin D status. The therapeutic window of vitamin D supplementation may be narrower than hitherto recognized. The prevention and/or correction of vitamin D deficiency/insufficiency with 800-1000 IU/daily of vitamin D or 10 µg/day of calcifediol are safe. Because of their potential harm, larger doses given on the long term or in intermittent regimens should not be selected. PMID: 32857334 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32857334?dopt=Abstract

Source: Aging Clinical and Experimental Research - August 27, 2020 Category: Geriatrics Authors: Rizzoli R Tags: Aging Clin Exp Res Source Type: research