Cytotoxic cell populations developed during treatment with tyrosine kinase inhibitors protect autologous CD4+ T cells from HIV-1 infection.

In conclusion, treatment with TKIs induced a potent antileukemic response that may also have antiviral effects against HIV-1 and CMV, suggesting that transient use of TKIs in HIV-infected patients could develop a sustained antiviral response that would potentially interfere with HIV-1 reservoir dynamics.
PMID: 32828803 [PubMed - as supplied by publisher]

Source: Biochemical Pharmacology - August 19, 2020 Category: Drugs & Pharmacology Authors: Vigón L, Rodríguez-Mora S, Luna A, Sandonís V, Mateos E, Bautista G, Luis Steegmann J, Climent N, Plana M, Pérez-Romero P, de Ory F, Alcamí J, García-Gutierrez V, Planelles V, Rosa López-Huertas M, Coiras M Tags: Biochem Pharmacol Source Type: research