Exposure of the abdominal aorta and visceral branches for hemorrhage control: A 2020 EAST Master Class Video Presentation

Conclusion The critical application of aortic exposure for hemorrhage control is a life-saving intervention if done rapidly and effectively. This requires a sound understanding of aortic anatomy and necessary steps for adequate exposure and subsequent repair. This video outlines the necessary steps to perform these interventions.
Source: Journal of Trauma and Acute Care Surgery - Category: Surgery Tags: 2020 EAST SURGICAL VIDEO Source Type: research

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Immune checkpoint inhibitors target checkpoint proteins with the goal of reinvigorating the host immune system and thus restoring antitumor response. With the dramatic increase in the use of checkpoint inhibitors for cancer treatment, surgical pathologists have assumed a major role in predicting the therapeutic efficacy (score based on programmed cell death ligand 1 immunohistochemistry and mismatch repair protein loss) as well as diagnosing the complications associated with these medications. Immune-related adverse events (irAEs) manifest as histologic changes seen in both the upper and lower gastrointestinal tract, and w...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Special Articles Source Type: research
During fenestrated endovascular aortic repair for complex visceral segment aneurysms, mesenteric vessels can be incorporated with a scallop or fenestration and reinforced with a bridging stent. The outcome of differences in visceral incorporation, specifically at the celiac axis, has not been previously contextualized to assess the cost/benefit of additional procedural complexity on patient outcomes perioperatively and at follow-up.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Session I – Thoracoabdominal Aorta Source Type: research
CONCLUSIONS: Visceral aortic thrombus present prior to abdominal aortic aneurysm repair and endovascular repair are both associated with an increased risk of future proximal aortic degeneration after infrarenal abdominal aortic aneurysm repair. These factors may predict patients at higher risk of developing proximal aortic aneurysms that may require complex aortic repairs.PMID:34165017 | DOI:10.1177/17085381211021282
Source: Vascular - Category: Surgery Authors: Source Type: research
Refractory celiac disease type II (RCD II), also referred to as “cryptic” enteropathy-associated T-cell lymphoma (EATL) or “intraepithelial T-cell lymphoma,” is a rare clonal lymphoproliferative disorder that arises from innate intraepithelial lymphocytes. RCD II has a poor prognosis and frequently evolves to EATL. The pathogenesis of RCD II is not well understood and data regarding the immunophenotypic spectrum of this disease and underlying genetic alterations are limited. To gain further biological insights, we performed comprehensive immunophenotypic, targeted next-generation sequencing, and chr...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
AbstractPurposeTo evaluate bridging stent geometry in patients who underwent branched endovascular aortic repair (B-EVAR) and to correlate the outcomes with intrinsic bridging stent characteristics aiming to identify the stent(s) that guarantees the best performance.MethodsPre-operative and post-operative computed tomography images of all patients undergoing B-EVAR between September 2016 and April 2019 were retrospectively analyzed. Following geometrical features were measured: target vessel take-off angle (TOA); longitudinal stent shortening; shape index (SI), intended as ratio between minimum and maximum diameter of the ...
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research
In the present study, we sought to discern the effects of splanchnic occlusive disease (SOD; renal, superior mesenteric, and/or celiac axis arteries) on spinal cord injury (SCI; paraparesis or paraplegia) and major adverse events (MAE) after descending thoracic aneurysm (DTA) and thoracoabdominal aortic aneurysm (TAAA) open repair.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
– To discern the impact of splanchnic occlusive disease (SOD: renal, superior mesenteric and/or celiac axis arteries) on spinal cord injury (SCI: paraparesis or paraplegia) and major adverse events (MAE) after descending thoracic (DTA) and thoraco-abdominal (TAAA) aneurysm open repair.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
AbstractSBA classification is still based on the location of the primary tumor, without genetic information. in the current study, an extensive genetic profile of SBA, was performed in order to identify and quantify targetable alterations for a future precision medicine in SBA. Clinical-pathological information for 24 patients affected by SBA were retrospectively reviewed. Whole genome analysis of the primary tumors was performed by the FOUNDATION Cdx technology. We carried out a functional enrichment analysis of the mutated genes with BioPlanet. Integrative clustering analysis revealed three distinct subtypes characterize...
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Our experience demonstrates that the use of VBX stents for ChEVAR and FEVAR is a safe and effective alternative to iCAST stents with excellent mid-term patency without a negative impact on endoleak frequency. PMID: 33302612 [PubMed - as supplied by publisher]
Source: The Journal of Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: J Cardiovasc Surg (Torino) Source Type: research
Sandro Ardizzone Giovanni Latella Claudia Mescoli Massimo Rugge Fabiana Zingone Valeria Barresi Rachele Ciccocioppo Paolo Pedrazzoli Gino Roberto Corazza Ombretta Luinetti Enrico Solcia Marco Paulli Antonio Di Sabatino Alessandro Vanoli Special AT-rich sequence-binding protein 2 (SATB2) is a transcription factor expressed by colonic cryptic epithelium and epithelial neoplasms of the lower gastrointestinal (GI) tract, as well as by small bowel adenocarcinomas (SBAs), though at a lower rate. Nevertheless, up to now, only small SBA series, often including a very limited number of Crohn&rsq...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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